Section: Application Domains

Imaging radiomics and genes to assess immunotherapy

Participants: Roger Sun, Théo Estienne, Enzo Batistella, Maria Vakalopoulou (in collaboration with Éric Deutsch and Nikos Paragios: Institut de Cancérologie Gustave Roussy, Therapanacea)

Because responses of patients with cancer to immunotherapy can vary in success, innovative predictors of response to treatment are urgently needed to improve treatment outcomes. We aimed to develop and independently validate a radiomics-based biomarker of tumour-infiltrating CD8 cells in patients included in phase 1 trials of anti-programmed cell death protein (PD)-1 or anti-programmed cell death ligand 1 (PD-L1) monotherapy. We also aimed to evaluate the association between the biomarker, and tumour immune phenotype and clinical outcomes of these patients. This work is in collaboration with the Institut de Cancérologie Gustave Roussy Paris.